Using multiple anti virus programs together?

Will I have any problems if I use Sophos Endpoint Security, Ad Aware Pro, and Advanced Systemcare v4 all together? I know you're not supposed to have more than 1 antivirus, but the first one is supposed to be a antivirus, the 2nd one is a antispyware, and the last one is a computer tuner, right? However, sometimes software have a broad gamut of protection that I'm not sure if they will slow down my computer.